- r/todayilearned - TIL of the Tolstoy Cup. A football competition involving only two teams, the Department of Peace Studies at the University of Bradford and the Department of War Studies at King's College London.
- Новости Германии: Гулагия
- <img class="result__icon__img" width="16" height="16" alt="" src="//external-content.duckduckgo.com/ip3/enacademic.com.cutestat.com.ico" name="i15" />
- EcoGen Biosciences Announces Plant Now, Pay Later Hemp Seed Program Designed To Support Farmers
- <img class="result__icon__img" width="16" height="16" alt="" src="//external-content.duckduckgo.com/ip3/www.hupso.com.ico" name="i15" />
- r/Glied - [NSFW] Jeder kennt diese sexy Biester. Ihr Name? Gliederwürmer
- Transporting a locomotive by horse and cart
- Cheese is a kind of meat a yellow tasty beef
- Subversive Acquisition LP Highlights InterCure's Accelerated Growth As The Leading Israeli Cannabis Company
- Рубрика "Ретроспектива"
- Cheese is a kind of meat, a yellow tasty beef
- TDIH: December 20, 1999. Macau is handed over to China by Portugal.
- АдА — Старый Мир
- TIL that 'Wind' by Akeboshi was inspired by The Stranglers' 'Golden Brown'.
- <img class="result__icon__img" width="16" height="16" alt="" src="//external-content.duckduckgo.com/ip3/tlg.today.ico" name="i15" />
- Резервный фонд для спокойствия бункерного
- <img class="result__icon__img" width="16" height="16" alt="" src="//external-content.duckduckgo.com/ip3/www.openadmintools.com.ico" name="i15" />
- Начинаются 888 дней Ада
- And that's just the facts (Face Jam)
- When we went to war with Chinese who wanted to stop Sri Lankan pirates
- Fachlehrer
- r/todayilearned - TIL of the Tolstoy Cup. A football competition involving only two teams the Department of Peace Studies at the University of Bradford and the Department of War Studies at King's College London.
- <img class="result__icon__img" width="16" height="16" alt="" src="//external-content.duckduckgo.com/ip3/www.facebook.com.ico" name="i15" />
- r/todayilearned - TIL the Canadian province of British Columbias coat of arms (upon which its flag was based) originally had the Union Flag beneath the setting sun; it was flipped after several years when Queen Elizabeth IIs heralds pointed out the sun n
- And that's just the facts (Face Jam)
- TIL that Dale Gribble from King of the Hill is named in homage to Mike Gribble, from Spike &amp; Mike's Twisted Animation Festival
- AzurRx BioPharma Provides Key Takeaways From Phase 2b OPTION 2 Clinical Trial Topline Results Conference Call
- r/todayilearned - TIL the Canadian province of British Columbia’s coat of arms (upon which its flag was based) originally had the Union Flag *beneath* the setting sun; it was flipped after several years when Queen Elizabeth II’s heralds pointed out “the s
- Transporting a locomotive by horse and cart
- Talk Talk Talk Talk
- <img class="result__icon__img" width="16" height="16" alt="" src="//external-content.duckduckgo.com/ip3/www.webwiki.com.ico" name="i15" />
- procesos vitales - Los diccionarios y las enciclopedias ...
- Enacademic
- <img class="result__icon__img" width="16" height="16" alt="" src="//external-content.duckduckgo.com/ip3/www.accessify.com.ico" name="i15" />
- All of y’all keep making fun of Saana but just FYI she won FOUR FCO and two challenges in her cycle.
- <img class="result__icon__img" width="16" height="16" alt="" src="//external-content.duckduckgo.com/ip3/www.hottg.com.ico" name="i15" />
- r/Glied - [NSFW] Jeder kennt diese sexy Biester. Ihr Name? Gliederwürmer
- Apple оштрафуют в Южной Корее за препятствование антимонопольному расследованию
- Densidad (física)
- Резервный фонд для спокойствия бункерного
- <img class="result__icon__img" width="16" height="16" alt="" src="//external-content.duckduckgo.com/ip3/enacademic.com.ico" name="i15" />
- Enacademic
- r/todayilearned - TIL That Jack in The Box created a fake boy band called the Meaty Cheese Boys because NSYNC had a CD promo with McDonald’s and Back Street Boys had it with Burger King.
- Saint-Chrysole church, Comines, France
- Enacademic
- Разыграй коллегу
- <img class="result__icon__img" width="16" height="16" alt="" src="//external-content.duckduckgo.com/ip3/www.easycounter.com.ico" name="i15" />
- Enacademic
- <img class="result__icon__img" width="16" height="16" alt="" src="//external-content.duckduckgo.com/ip3/tgstat.com.ico" name="i15" />
- Ellomay Capital Announces The Filing Of The Annual Report On Form 20-F For 2020
Posted: 31 Mar 2021 01:35 PM PDT |
Posted: 31 Mar 2021 01:56 PM PDT https://ok.ru/video/2186437200391 Министр здравоохранения Германии Шпан просто прошёл мимо, видя как полицейский заткнул протестующей рот. Написал xaerostar на mp.d3.ru / комментировать |
Posted: 31 Mar 2021 01:31 PM PDT |
EcoGen Biosciences Announces Plant Now, Pay Later Hemp Seed Program Designed To Support Farmers Posted: 31 Mar 2021 01:39 PM PDT GRAND JUNCTION, Colo., March 31, 2021 /PRNewswire/ -- EcoGen Biosciences ("EcoGen" or the "Company"), a leading vertically-integrated manufacturer and supplier of hemp-derived specialty ingredients, proprietary formulations, and private-label finished products in the United States, today introduced the EcoGen "Plant Now, Pay Later" program. The Plant Now, Pay Later program enables hemp farmers to have access to affordable, high-cannabidiol (CBD) hemp genetics without the upfront cost of purchasing seeds prior to planting, which mitigates many of the risks farmers face, such as depleting their capital upfront. The program gives them the latitude to invest more into their farming operations pre-harvest. Through the program, hemp farmers are offered competitively scaled rates on EcoGen's exclusive hemp genetics. Participating clients have the option to:
The Plant Now, Pay Later program provides hemp farmers with the opportunity to focus financial resources on growing and processing without the financial burden often required to acquire seeds for hemp cultivation. "As the market prices and demand for raw hemp materials continues to evolve, so must the relationships within the supply chain," said Garrett Bain, President of EcoGen and Chief Commercial Officer of Kadenwood, LLC. "As a fully integrated hemp company, with operations in genetics, cultivation, extraction, refinement, and finished goods, EcoGen has a unique opportunity to mitigate risks for fellow hemp industry members. We understand and appreciate that farmers rely on our specialized genetics in order to successfully grow first rate, sellable crops. We believe in our genetics so much so that we are willing to take the risk on the front end, let our farmers grow with our seeds and either pay after harvest, or provide the biomass as payment for the cost of the seeds. We feel this is a win-win for our customers and for EcoGen and we are proud to support our industry further with the establishment of this program." Andrei McQuillian, Head of Global Sales and Marketing of EcoGen, said: "We foresee many if not all of our longtime and new hemp farming partners taking advantage of the program. As we further develop the ethos of our company, we know that we are grounded in the belief that all business dealings should be both mutually beneficial and not damaging to the world around us, and we also stand to make a positive impact on the industry as a whole. This program is the first of many embodiments of this ethos and we hope that those on the frontlines of growing hemp not only utilize the program, but that it enables them the most success in this year's harvest as possible." To learn more about the EcoGen "Plant Now, Pay Later" program, please visit https://ecogenbiosciences.com/plant-now-pay-later and for more information on EcoGen, including information on becoming a customer, visit ecogenbiosciences.com . About EcoGen Biosciences EcoGen Biosciences (EcoGen) is the leading vertically-integrated manufacturer and supplier of hemp-derived specialty ingredients in North America. Using proprietary equipment, processes, and formulations, EcoGen has developed a broad range of the highest quality ingredients and customized formulations for a broad range of industries. Founded in 2016, EcoGen is the first seed-to-sale CBD manufacturer, known for manufacturing the purest CBD raw materials and finished products. The company is also a leader in international distribution with CBD isolate, water-soluble CBD (Nano), and THC-free CBD distillate. As the leader in hemp genetics, EcoGen promotes sustainable agriculture, using its proprietary processing and extraction technology to ensure the highest quality products at the lowest price making cannabinoids more accessible to the world. About Kadenwood, LLC Founded in 2019, Kadenwood is a privately held consumer products lifestyle company relentlessly focused on shaping CBD into a trusted and safe mainstream wellness category. To drive this mission, Kadenwood is backed by decades of CPG marketing and category innovation expertise and industry-leading, vertically-integrated CBD farming to ensure quality CBD oil from seed-to-shelf that contains no THC. In 2019, Kadenwood launched its first branded products under LEVEL SELECT™ in personal care. Public Relations Contact Cassandra Dowell CMW Media cassandra@cmwmedia.com858-264-6600 View original content: http://www.prnewswire.com/news-releases/ecogen-biosciences-announces-plant-now-pay-later-hemp-seed-program-designed-to-support-farmers-301260053.html SOURCE EcoGen Biosciences |
Posted: 31 Mar 2021 01:31 PM PDT |
r/Glied - [NSFW] Jeder kennt diese sexy Biester. Ihr Name? Gliederwürmer Posted: 31 Mar 2021 01:34 PM PDT |
Transporting a locomotive by horse and cart Posted: 31 Mar 2021 01:34 PM PDT |
Cheese is a kind of meat a yellow tasty beef Posted: 31 Mar 2021 01:35 PM PDT |
Posted: 31 Mar 2021 01:36 PM PDT InterCure , dba Canndoc , Announces Record-Breaking Q4 Results with Positive EBITDA and Cash Flow InterCure Acquires Four New Medical Cannabis Pharmacies and Increase s 2021 Target to 10 Retail Locations Canndoc Successfully Launches First Product Line of California Genetic Strains Grown in Israel TORONTO, March 31, 2021 (GLOBE NEWSWIRE) -- SUBVERSIVE ACQUISITION LP (TSX: SVX.U, NEO: SVX.U, OTCQX: SBVRF) (" SVX") announced today that InterCure Ltd. (dba Canndoc) (TASE: INCR) (" InterC ure"), Israel's leading cannabis company and SVX's intended target for its "Qualifying Transaction" (the " Transaction"), has reported its fourth quarter and full-year 2020 results (the " InterCure Press Release"). InterCure has announced that it accelerated its growth and distribution footprint in Israel by expanding its retail footprint with the acquisition of four new medical cannabis pharmacies. InterCure Fourth Quarter and Full Year 2020 Hig h lights from the InterCure Press Release
*EBITDA for InterCure's cannabis sector Pharmacy Expansion InterCure announced that, through its subsidiary CannOlam, it has acquired four pharmacies in Israel which will operate under the Company's Givol medical cannabis pharmacy chain. With the acquisition of these four additional pharmacies, InterCure is expected to expand the Givol retail chain to 10 locations in 2021, compared to the six locations previously announced. InterCure noted that the Givol premium pharmacy chain serves Israel's growing medical cannabis patient community in every major region in Israel. By providing premium products and personal consulting on medical cannabis, InterCure expects the Givol pharmacies will help serve over 85,000 licensed medical cannabis patients in Israel. Successful Product Launch InterCure also announced that it became the first Israeli cannabis company to grow and commercialize California strains in Israel. InterCure noted that the unique genetics of four original California cannabis strains were the first grown in InterCure's southern facility, the largest and most advanced cannabis production site in Israel with operational grounds of 300,000 square feet. InterCure added that its exclusive California genetics products, branded as Canndoc Cali, successfully launched in the first quarter of 2021 and sold out, driving InterCure's growth and market share as demand continues to grow for its unique and exclusive brands and products. Attached as Schedule A to this press release is a translated version of the full InterCure Press Release. As previously announced by SVX, the Transaction highlights include:
Completion of the Transaction, which is expected by April 8, 2021, remains subject to the satisfaction or waiver of certain customary conditions including, among other things, requisite shareholder and regulatory approvals. SVX's Annual Audited Financial Statements and MD&A SVX is reporting is financial results for the year ending December 31, 2020. SVX's audited financial statements along with its management discussion and analysis for the noted period have been filed on the System for Electronic Document Analysis and Retrieval and may be viewed by unitholders and interested parties under SVX's profile at www.sedar.com. About SVX Subversive Acquisition LP is a limited partnership established under the Limited Partnerships Act (Ontario) formed for the purpose of effecting, directly or indirectly, an acquisition of one or more businesses or assets, by way of a merger, amalgamation, arrangement, equity exchange, asset acquisition, equity purchase, reorganization, or any other similar business combination involving SVX that will qualify as its qualifying transaction for the purposes of the rules of the TSX and Neo Exchange Inc. SVX is a special purpose acquisition corporation for the purposes of the rules of the TSX and Neo Exchange Inc. For more information, visit https://www.subversivecapital.com/svx. About Subversive Capital Subversive Capital is a leading investment firm dedicated to investing in radical companies whose core missions subvert the status quo. With almost a decade of experience in the global cannabis industry, Subversive Capital has lead investments in some of the most successful transactions in the industry including the recent launch and closing transaction of Subversive Capital Acquisition Corp. to form The Parent Company (TPCO Holding Corp.) currently traded on the Neo Exchange and OTCQX. For more information, visit www.subversivecapital.com About InterCure and Canndoc InterCure (TASE: INCR) is the first public company on the Tel Aviv Stock Exchange to hold a valid and permanent license for the medical cannabis value chain through its 100% ownership in Canndoc. Canndoc is a GMP medical cannabis producer. Licensed by the Israeli Ministry of Health since 2008, Canndoc is a leading pioneer in the research, cultivation, production, and distribution of pharma-grade cannabis-based products to patients, hospitals, pharmacies, research and governmental organizations. Through its strategic exclusive collaboration with world leaders, distribution agreement with SLE (100% owned by Teva Pharmaceutical Industry) and long-term sales agreements, Canndoc is well-positioned as a leading and significant player in pharma-grade medical cannabis in Israel, Europe and the United Kingdom. For more information: http://www.canndoc.com Non-IFRS Measures This press release makes reference to certain non-IFRS financial measures. EBITDA, as defined by InterCure, means earnings before interest, income taxes, depreciation and amortization for a quarter annualized. This measure is not a recognized measure under IFRS, does not have a standardized meaning prescribed by IFRS and is therefore unlikely to be comparable to similar measures presented by other companies. InterCure's method of calculating this measure may differ from methods used by other entities and accordingly, this measure may not be comparable to similarly titled measured used by other entities or in other jurisdictions. InterCure use this measure because it believes it provides useful information to both management and investors with respect to the operating and financial performance of the company. Forward‐Looking Statements This press release may contain forward-looking information within the meaning of applicable securities legislation which reflects SVX's current expectations regarding future events. The words "will", "expects", "intends" and similar expressions are often intended to identify forward-looking information, although not all forward-looking information contains these identifying words. Specific forward-looking information contained in this press release includes, but is not limited to: statements concerning InterCure's projected growth and operations during 2021 the completion and proposed terms of, and matters relating to, the Transaction and the satisfaction of the required closing conditions . Forward-looking information is based on a number of assumptions and is subject to a number of risks and uncertainties, many of which are beyond SVX's control, which could cause actual results and events to differ materially from those that are disclosed in or implied by such forward-looking information. Such risks and uncertainties include, but are not limited to: failure to complete the Transaction, inability to obtain requisite regulatory or shareholder approvals, changes in general economic, business and political conditions, changes in applicable laws, the U.S. and Canadian regulatory landscapes and enforcement related to cannabis, changes in public opinion and perception of the cannabis industry, reliance on the expertise and judgment of senior management, as well as the factors discussed under the heading "Risk Factors" in the non-offering prospectus pertaining to the Transaction which is available on SEDAR at www.sedar.com. SVX undertakes no obligation to update such forward-looking information, whether as a result of new information, future events or otherwise, except as expressly required by applicable law. SCHEDULE A INTERCURE: Record results, consistent growth and a significant increase in profits as the company prepares for merger with SPAC next week In the fourth quarter of 2020, annual sales rate of over NIS 108 million and the annual profitability rate of NIS 35 million - the highest in the industry: Record revenues in Q4 of NIS 27 million; Growth of more than 15 times compared to the corresponding quarter And over 20% compared to the previous quarter; Adjusted profit - EBITDA reaches new high of NIS 9 million - 32% of total revenues; Positive cash flow from operating activities of NIS 9.4 million in the quarter The company supplied a record amount of medical cannabis products in Q4 t hanks to the growing demand for the company's hig h- quality products The company expects to close merger with SPAC at a value of $300 million USD for InterCure shareholders next week Commencement of trading of the Company's shares on the Toronto Stock Exchange (TSX) is expected immediately upon completion of the transaction Additionally, the company prepares to begin the process of listing on the NASDAQ The SPAC has a cumulative total of $290 million USD, upon completion of the transaction at the InterCure will have at least $55 million USD in liquidity March 31, 2021: InterCure (TASE: INCR) reports record results for the fourth quarter and for the whole of 2020. In the past year, the company has established itself as the largest and leading cannabis company in Israel and as an international growth company with consistent and rapid growth in revenue and profit, for the eighth consecutive quarter. In the fourth quarter of 2020, the company posted a record revenue of over NIS 27 million, which represents an annual revenue rate of over NIS 108 million, the highest in the industry. Throughout the year, the company showed consistent accelerated growth from quarter to quarter, revenue from InterCure's cannabis sector reached NIS 65 million in 2020, with more than 40% of total revenue recorded in the fourth quarter of the year. The growth of more than 7 times in 2020 revenues reflects the competitive advantage, high product quality and implementation of the company's domestic and international cooperation strategy. Following the successful commercial operation of the southern site in Nir Oz, which positions the company as the largest grower in Israel, along with the expansion of its leading medical cannabis pharmacy chain 'Givol', InterCure expects that the growth and improvement trend in profitability will continue during 2021. Merger with SPAC: The Company recently reported the signing of a final merger agreement with Subversive Acquisition as part of a SPAC transaction. The SPAC raised $290 million, of which $65 million was privately raised. The merger represents a value of $300 million to InterCure's shareholders, which is an adequate overflow of value and an expression of confidence in the company's capabilities and vision. These days the company is working together with the SPAC's management team to successfully complete the merger process expected next week (4.8.2021). As part of the completion of the move, InterCure is expected to begin trading on the Toronto Stock Exchange (TSX) and also register for trading on the Nasdaq Stock Exchange. The significant capital raising from international investors and the expected listing on leading stock exchanges in the world will enable InterCure to expand its investor base and establish additional significant growth engines for the continued momentum of growth and expansion of activity in Israel and around the world. The company is also preparing for accelerated commercial growth of an adult use cannabis market, CBD wellness marker, subject to the expected regulatory changes. The company sees CBD products as a significant growth engine. In this context, InterCure entered a strategic and exclusive collaboration with Charlotte's Web, which has the largest and leading CBD brand in the world. In addition, the company is expanding its operations through additional collaborations with leading companies and brands in Israel and around the world. The company's revenues in Q4 grew to a record turnover of approximately NIS 27 million for the quarter, representing an annual rate of approximately NIS 108 million, a growth of 15 times compared with the corresponding quarter last year and a rate of over 20% compared to the previous quarter in 2019, which amounted to NIS 10 million. This was a result of high demand for the company's high quality product lines, market growth, increase in the company's market share, implementation of commercial agreements with pharmacies, international collaborations and the first consolidation of CannOlam's operations. The rate of revenue in the fourth quarter in annual terms stands at approximately NIS 108 million. The company estimates that the growth trend in revenues is expected to continue during 2021 as well. In the company's estimation, the success of production at the company's southern site, which is one of the largest and most advanced in Israel and around the world, is expected to improve the company's gross profit. The company shows a continuous improvement in operating profit when in the fourth quarter of 2020 the operating profit reached NIS 8 million in the quarter, compared with a negative operating profit of NIS 3 million in the corresponding period last year. The increase in operating profit was mainly due to growth in revenue, improvement in gross profit and management of fixed costs. The growth in revenue, improvement in gross profit and fixed costs management, the company presents positive EBITDA of NIS 9 million in the quarter, representing an annual rate of NIS 35 million, a significant improvement compared to a negative EBITDA of approximately NIS 3 million in the fourth quarter of previous year. The company enjoys high demand for its high-quality product lines, and shows a continuous improvement in all profitability indices, which is reflected in both the improvement in operating profitability and a continuous improvement with positive cash flow from operating activities. In the fourth quarter, the trend of improvement continued, and the company generated a positive cash flow from operating activities in the amount of NIS 9 million, compared with a negative cash flow in the previous quarter and in the entire previous year. Positive cash flow from operating activities of NIS 9.4 million in the quarter and NIS 7.7 million throughout the year. Most of the change is due to a significant increase in the company's turnover and working capital. Cash and cash value of NIS 38 million (consolidated InterCure). Ehud Barak, Chairman of InterCure, said: "In 2020 InterCure has proven that it successfully implements profitable growth while becoming a leading force in the local and international market. This is thanks to the great trust from both the patient community, pharmacists and doctors, our business partners and our dedicated staff. Now, the company is well positioned to continue to realize its vision in Israel and around the world and to enjoy the full range of regulatory changes expected with the process of recognizing the virtues and benefits of the cannabis plant. The merger and listing for trading on the world's leading stock exchanges will ensure our ability to further accelerate our business operations, improve the quality of life of patients in many territories around the world and create value for the company and its shareholders." FOR FURTHER INFORMATION PLEASE CONTACT:Subversive Acquisition LPInvestors:Investor@subversivecapital.comMedia:Berrin NoorataBerrin@subversivecapital.comInterCure Ltd.Adam Haliva, Global Investor Relationsadam@canndoc-pharma.com, (972) 54-646-8778 |
Posted: 31 Mar 2021 01:46 PM PDT А теперь сравните Написал xaerostar на mp.d3.ru / комментировать |
Cheese is a kind of meat, a yellow tasty beef Posted: 31 Mar 2021 01:35 PM PDT |
TDIH: December 20, 1999. Macau is handed over to China by Portugal. Posted: 31 Mar 2021 01:35 PM PDT |
Posted: 31 Mar 2021 01:51 PM PDT «Ада» — российская индастриал–метал группа, основанная в 2005 году в Челябинске. Своё название группа «Ада» взяла в честь математика Ады Лавлейс, которая известна прежде всего созданием описания вычислительной машины. Написал zorg-kirill на industrial.d3.ru / комментировать |
TIL that 'Wind' by Akeboshi was inspired by The Stranglers' 'Golden Brown'. Posted: 31 Mar 2021 01:35 PM PDT |
Posted: 31 Mar 2021 01:31 PM PDT |
Резервный фонд для спокойствия бункерного Posted: 31 Mar 2021 01:35 PM PDT |
Posted: 31 Mar 2021 01:31 PM PDT |
Posted: 31 Mar 2021 01:51 PM PDT 30–31 марта 2021–го года на многих уфологических площадках стал появляться ролик, снятый или в Мексике, или в Бразилии. НЛО в нём фигурирует в ТАКОЙ детализации, что можно первым делом подумать на фейк, однако, там есть ряд интересных моментов, о которых мы скажем ниже: «Билли», он же Эдуард Альберт Майер – человек очень интересный. Первый контакт с пришельцами у него произошел в 1942–м году в возрасте 5–ти лет, после чего "марсиане" ребеночка оставили без присмотра и вернулись к нему только в 1975–м году, рассказав много интересных вещей.
Написал alcab на bestiarius.d3.ru / комментировать |
And that's just the facts (Face Jam) Posted: 31 Mar 2021 01:35 PM PDT |
When we went to war with Chinese who wanted to stop Sri Lankan pirates Posted: 31 Mar 2021 01:35 PM PDT |
Posted: 31 Mar 2021 01:35 PM PDT |
Posted: 31 Mar 2021 01:35 PM PDT |
Posted: 31 Mar 2021 01:31 PM PDT |
Posted: 31 Mar 2021 01:35 PM PDT |
And that's just the facts (Face Jam) Posted: 31 Mar 2021 01:35 PM PDT |
Posted: 31 Mar 2021 01:35 PM PDT |
Posted: 31 Mar 2021 01:35 PM PDT DELRAY BEACH, Fla., March 31, 2021 (GLOBE NEWSWIRE) -- AzurRx BioPharma, Inc. (NASDAQ: AZRX), ("AzurRx" or the "Company"), a clinical stage biopharmaceutical company specializing in the development of targeted, non-systemic therapies for gastrointestinal (GI) diseases, today provided key takeaways from its conference call reporting on the topline results from its Phase 2b OPTION 2 clinical trial investigating MS1819 in cystic fibrosis (CF) patients with exocrine pancreatic insufficiency (EPI). The conference call, held on March 31, 2021, at 4:30 p.m. ET, featured James Sapirstein, President, CEO and Chairman of AzurRx, and Dr. James Pennington, Chief Medical Officer, discussing the recently completed OPTION 2 study, and the company's plans to develop an optimized formulation of MS1819 for ongoing clinical investigation. OPTION 2 was designed as a Phase 2b multi-center study to investigate the safety, tolerability and efficacy of MS1819 (in enteric capsules) in a head-to-head comparison against the current porcine enzyme replacement therapy (PERT) standard of care for the treatment of exocrine pancreatic insufficiency (EPI) in patients with cystic fibrosis. The primary efficacy endpoint was the coefficient of fat absorption (CFA), with secondary endpoints of stool weight, signs and symptoms of malabsorption and coefficient of nitrogen absorption (CNA). The trial also included an extension arm that used an immediate release MS1819 capsule, allowing the Company to compare data from the existing arm that uses enteric (delayed release) capsules with data from the new arm, and ultimately select the optimal delivery method. Discussing the topline results of OPTION 2 during the conference call, Mr. Sapirstein commented, "To summarize, the best word to describe the OPTION 2 topline results is mixed. MS1819 demonstrated itself to be safe and well-tolerated and data from OPTION 2, and other Phase 2 clinical trials, clearly demonstrate drug activity. However, OPTION 2 did not consistently meet the primary efficacy endpoint. Some patients were able to achieve CFA at levels beyond what is required to demonstrate non-inferiority with PERT therapies, but the majority did not, and as such, we did not meet our trial goal." Mr. Sapirstein continued, "The underlying cause of the drug's uneven efficacy performance in OPTION 2, we believe, lies with the enteric capsule formulation. While the enteric coating protects the capsule from breaking down in the stomach acid, it also appears to dissolve too slowly in the small intestine to release the lipase enzyme in time to aid with proper digestion and nutrient absorption." "To that end, we are planning to pursue a new formulation for MS1819, this one a capsule filled with acid-resistant granules, or microbeads, similar to what is used in CREON®, ZENPEP® and other PERT therapies. Such a capsule would dissolve in the stomach, disperse the beads, and then pass through to the small intestine where the beads would break down and release the lipase enzyme so that it thoroughly mixes with food as it is being digested." Mr. Sapirstein concluded, "We are moving full force with developing the optimal formulation technology for MS1819 and have already initiated discussions with contract manufacturers to accelerate the process. This will require additional time and resources. Yet we are fortunate, through financing efforts that have raised an aggregate of approximately $22.5 million in the first quarter of 2021, to have sufficient capital currently on hand to fund this development and, within the next year or so, initiate a further Phase 2 study to evaluate efficacy, without substantially delaying our clinical development initiatives in other areas. We firmly believe the cost-benefit ratio with MS1819 is clearly in our favor. The drug's mechanism of action is known and proven, it offers numerous therapeutic, safety and compliance advantages over today's standard of care, and remains less cumbersome to manufacture. Based on these factors, we believe that should this optimized formulation prove successful in the clinic - and we have every reason to believe it will - MS1819 could eventually become the gold standard treatment for EPI in patients with cystic fibrosis and chronic pancreatitis." An audio webcast of the conference call will be accessible via the Investors section of the AzurRx website at www.azurrx.com. An archive of the webcast will remain available for approximately 90 days. Phase 2 OPTION 2 Trial DesignThe Phase 2b OPTION 2 multi-center trial was designed to investigate the safety, tolerability and efficacy of MS1819 (2.2 and 4.4 gram doses in enteric capsules) in a head-to-head comparison versus the current standard of care, porcine pancreatic enzyme replacement therapy pills. The OPTION 2 trial was an open-label, crossover study, conducted in 15 sites in the U.S. and Europe. A total of 30 CF patients 18 years or older were enrolled. MS1819 was administered in enteric capsules to provide gastric protection and allow optimal delivery of enzyme to the duodenum. Patients were first randomized into two cohorts: to either the MS1819 arm, where they received a 2.2 gram daily oral dose of MS1819 for three weeks; or to the PERT arm, where they received their pre-study dose of PERT pills for three weeks. After three weeks, stools were collected for analysis of coefficient of fat absorption. Patients were then crossed over for another three weeks of the alternative treatment. After three weeks of cross-over therapy, stools were again collected for analysis of CFA. A parallel group of patients were randomized and studied in the same fashion, using a 4.4 gram daily dose of MS1819. All patients were followed for an additional two weeks after completing both crossover treatments for post study safety observation. Patients were assessed using descriptive methods for efficacy, comparing CFA between MS1819 and PERT arms, and for safety. About MS1819MS1819 is a recombinant lipase enzyme for the treatment of exocrine pancreatic insufficiency associated with cystic fibrosis and chronic pancreatitis. MS1819, supplied as an oral non-systemic biologic capsule, is derived from the Yarrowia lipolytica yeast lipase and breaks up fat molecules in the digestive tract of EPI patients so that they can be absorbed as nutrients. Unlike the standard of care, the MS1819 synthetic lipase does not contain any animal products. About Exocrine Pancreatic InsufficiencyEPI is a condition characterized by deficiency of the exocrine pancreatic enzymes, resulting in a patient's inability to digest food properly, or maldigestion. The deficiency in this enzyme can be responsible for greasy diarrhea, fecal urge and weight loss. There are more than 30,000 patients in the U.S. with EPI caused by cystic fibrosis according to the Cystic Fibrosis Foundation and approximately 90,000 patients in the U.S with EPI caused by chronic pancreatitis according to the National Pancreas Foundation. Patients are currently treated with porcine pancreatic enzyme replacement pills. About AzurRx BioPharma, Inc.AzurRx BioPharma, Inc. (AZRX) - Get Report is a clinical stage biopharmaceutical company specializing in the development of targeted, non-systemic therapies for gastrointestinal (GI) diseases. The Company has a pipeline of three gut-restricted GI assets. The lead therapeutic candidate is MS1819, a recombinant lipase for the treatment of exocrine pancreatic insufficiency (EPI) in patients with cystic fibrosis and chronic pancreatitis, currently in two Phase 2 CF clinical trials. AzurRx is launching two clinical programs using proprietary formulations of niclosamide, a pro-inflammatory pathway inhibitor; FW-1022, for COVID-19 gastrointestinal infections, and FW-420, for grade 1 Immune Checkpoint Inhibitor-Associated Colitis and diarrhea in oncology patients. The Company is headquartered in Delray Beach, Florida with clinical operations in Hayward, California. For more information visit www.azurrx.com. Forward-Looking Statement This press release may contain certain statements relating to future results which are forward-looking statements. It is possible that the Company's actual results and financial condition may differ, possibly materially, from the anticipated results and financial condition indicated in these forward-looking statements, depending on factors including whether results obtained in preclinical and nonclinical studies and clinical trials will be indicative of results obtained in future clinical trials; whether preliminary or interim results from a clinical trial will be indicative of the final results of the trial; and the impact of the coronavirus (COVID-19) pandemic on the Company's operations and current and planned clinical trials, including potential delays in clinical trial recruitment and participation. Additional information concerning the Company and its business, including a discussion of factors that could materially affect the Company's financial results are contained in the Company's Annual Report on Form 10-K for the year ended December 31, 2019 under the heading "Risk Factors," as well as the Company's subsequent filings with the Securities and Exchange Commission. All forward-looking statements included in this press release are made only as of the date of this press release, and we do not undertake any obligation to publicly update or correct any forward-looking statements to reflect events or circumstances that subsequently occur or of which we hereafter become aware. For more information: AzurRx BioPharma, Inc.1615 South Congress AvenueSuite 103Delray Beach, Florida 33445Phone: (646) 699-7855 info@azurrx.com Media contact: Tiberend Strategic Advisors, Inc. Johanna Bennett/Ingrid Mezo(212) 375-2665/(646) 604-5150 jbennett@tiberend.com / imezo@tiberend.com |
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procesos vitales - Los diccionarios y las enciclopedias ... Posted: 31 Mar 2021 01:55 PM PDT conjunto de acciones que llevan a cabo los organismos vivos y que los diferencian de los objetos inanimados. Algunos de los procesos vitales más importantes son: Metabolismo: es la suma de todos los procesos químicos que tienen lugar en un… |
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All of y’all keep making fun of Saana but just FYI she won FOUR FCO and two challenges in her cycle. Posted: 31 Mar 2021 01:35 PM PDT |
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Apple оштрафуют в Южной Корее за препятствование антимонопольному расследованию Posted: 31 Mar 2021 01:49 PM PDT После урегулирования антимонопольных обвинений в Южной Корее местное подразделение Apple будет всё же оштрафовано на $265 000 за то, что якобы препятствовало проведению расследования, пишет ресурс The Korea Herald. Комиссия по справедливой торговле Южной Кореи (KFTC) утверждает, что Apple предприняла шаги, чтобы помешать её рейду с проверкой офисов в 2016 году. Как сообщается, Apple заблокировала доступ в интернет и отказалась предоставить соответствующую документацию. |
Posted: 31 Mar 2021 01:55 PM PDT En física el término densidad considera la cantidad de masa contenida en determinado volumen y se utiliza en términos absolutos o en términos relativos. La densidad relativa expresa la relación entre la masa de una sustancia y la masa del mismo volumen de agua, resultando una magnitud adimensional. La densidad absoluta expresa la masa por unidad de volumen, que más apropiadamente se ... |
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Ellomay Capital Announces The Filing Of The Annual Report On Form 20-F For 2020 Posted: 31 Mar 2021 01:40 PM PDT TEL AVIV, Israel, March 31, 2021 /PRNewswire/ -- Ellomay Capital Ltd.(NYSE American; TASE: ELLO) ("Ellomay" or the "Company"), a renewable energy and power generator and developer of renewable energy and power projects in Europe and Israel, today announced the filing of its Annual Report on Form 20-F for the year ended December 31, 2020 with the Securities and Exchange Commission. A copy of the Annual Report on Form 20-F is available to be viewed and downloaded from the Investor Relations section of the Company's website at http://www.ellomay.com. The Company will provide a hard copy of the Annual Report on Form 20-F, including the Company's complete audited financial statements, free of charge to its shareholders upon request. About Ellomay Capital Ltd. Ellomay is an Israeli based company whose shares are registered with the NYSE American and with the Tel Aviv Stock Exchange under the trading symbol "ELLO". Since 2009, Ellomay Capital focuses its business in the renewable energy and power sectors in Europe and Israel. To date, Ellomay has evaluated numerous opportunities and invested significant funds in the renewable, clean energy and natural resources industries in Israel, Italy and Spain, including:
For more information about Ellomay, visit http://www.ellomay.com. Contact: Kalia Weintraub CFO Tel: +972-(3)-797-1111 Email: hilai@ellomay.com View original content: http://www.prnewswire.com/news-releases/ellomay-capital-announces-the-filing-of-the-annual-report-on-form-20-f-for-2020-301260005.html SOURCE Ellomay Capital Ltd |
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